Abstract
A series of 2(Z)-2-benzylidene-6,7-dihydroxybenzofuran-3[2H]-ones was identified as potent inhibitors of bacterial chorismate synthase. The 2'-hydroxy-4'-pentoxy analogue 33 is a potent inhibitor of Streptococcus pneumoniae chorismate synthase.
MeSH terms
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Benzofurans / chemical synthesis*
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Benzofurans / pharmacology*
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Benzyl Compounds / chemical synthesis*
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Benzyl Compounds / pharmacology*
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Cloning, Molecular
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / pharmacology*
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Phosphorus-Oxygen Lyases / antagonists & inhibitors*
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Reverse Transcriptase Polymerase Chain Reaction
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Shikimic Acid / pharmacology
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Streptococcus pneumoniae / drug effects
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Streptococcus pneumoniae / enzymology
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Streptococcus pneumoniae / genetics
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Structure-Activity Relationship
Substances
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Benzofurans
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Benzyl Compounds
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Enzyme Inhibitors
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Shikimic Acid
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chorismate synthase
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Phosphorus-Oxygen Lyases