A series of 2(Z)-2-benzylidene-6,7-dihydroxybenzofuran-3[2H]-ones as inhibitors of chorismate synthase

Bioorg Med Chem Lett. 2003 Feb 10;13(3):423-6. doi: 10.1016/s0960-894x(02)00957-5.

Abstract

A series of 2(Z)-2-benzylidene-6,7-dihydroxybenzofuran-3[2H]-ones was identified as potent inhibitors of bacterial chorismate synthase. The 2'-hydroxy-4'-pentoxy analogue 33 is a potent inhibitor of Streptococcus pneumoniae chorismate synthase.

MeSH terms

  • Benzofurans / chemical synthesis*
  • Benzofurans / pharmacology*
  • Benzyl Compounds / chemical synthesis*
  • Benzyl Compounds / pharmacology*
  • Cloning, Molecular
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / pharmacology*
  • Phosphorus-Oxygen Lyases / antagonists & inhibitors*
  • Reverse Transcriptase Polymerase Chain Reaction
  • Shikimic Acid / pharmacology
  • Streptococcus pneumoniae / drug effects
  • Streptococcus pneumoniae / enzymology
  • Streptococcus pneumoniae / genetics
  • Structure-Activity Relationship

Substances

  • Benzofurans
  • Benzyl Compounds
  • Enzyme Inhibitors
  • Shikimic Acid
  • chorismate synthase
  • Phosphorus-Oxygen Lyases